Publications

2019

Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.

Kargas V, Castro-Hartmann P, Escudero-Urquijo N, Dent K, Hilcenko C, Sailer C, Zisser G, Marques-Carvalho MJ, Pellegrino S, Wawiórka L, Freund SM, Wagstaff JL, Andreeva A, Faille A, Chen E, Stengel F, Bergler H, Warren AJ.

Elife (2019) 8. pii: e44904. doi: 10.7554/eLife.44904. [Abstract] [Full Text]

2018

Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN.

Elf S*, Abdelfattah NS*, Baral AJ*, Beeson D, Rivera JF, Ko A, Florescu N, Birrane G, Chen E, Mullally A. (*denotes equal contribution)

Blood (2018) 131:782-786 [Abstract] [Full Text]

2016

Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation.

Elf S*, Abdelfattah NS*, Chen E*, Perales-Patón J, Rosen EA, Ko A, Peisker F, Florescu N, Giannini S, Wolach O, Morgan EA, Tothova Z, Losman JA, Schneider RK, Al-Shahrour F, Mullally A (*denotes equal contribution)

Cancer Discovery (2016) 6:368-81 [Abstract] [Full Text]

 

JAK2V617F mediates resistance to DNA damage-induced apoptosis by modulating FOXO3A localization and Bcl-xL deamidation

Ahn JS, Li J, Chen E, Kent DG, Park HJ, Green AR.

Oncogene (2016) 35:2235-46 [Abstract] [Full Text]

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9.

Schneider RK, Schenone M, Ferreira MV, Kramann R, Joyce CE, Hartigan C, Beier F, Brümmendorf TH, Germing U, Platzbecker U, Büsche G, Knüchel R, Chen MC, Waters CS, Chen E, Chu LP, Novina CD, Lindsley RC, Carr SA, Ebert BL

Nature Medicine (2016) 22:288-97 [Abstract] [Full Text]

 

STAT1 activation in association with JAK2 exon 12 mutations.

Godfrey AL, Chen E, Massie CE, Silber Y, Pagano F, Bellosillo B, Guglielmelli P, Harrison CN, Reilly JT, Stegelmann F, Bijou F, Lippert E, Boiron JM, Döhner K, Vannucchi AM, Besses C, Green AR 

Haematologica (2016) 101:e15-19 [Abstract] [Full Text]

 

2015

RECQL5 suppresses oncogenic JAK2-induced replication stress and genomic instability

Chen E, Ahn JS, Sykes DB, Breyfogle LJ, Godfrey AL, Nangalia J, Ko A, DeAngelo DJ, Green AR, Mullally A. 

Cell Reports (2015) 13:2345-2352 [Abstract] [Full Text

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

Tapper W, Jones AV, Kralovics R, Harutyunyan AS, Zoi K, Leung W, Godfrey AL, Guglielmelli P, Callaway A, Ward D, Aranaz P, White HE, Waghorn K, Lin F, Chase A, Baxter EJ, Maclean C, Nangalia J, Chen E, Evans P, Short M, Jack A, Wallis L, Oscier D, Duncombe AS, Schuh A, Mead AJ, Griffiths M, Ewing J, Gale RE, Schnittger S, Haferlach T, Stegelmann F, Döhner K, Grallert H, Strauch K, Tanaka T, Bandinelli S, Giannopoulos A, Pieri L, Mannarelli C, Gisslinger H, Barosi G, Cazzola M, Reiter A, Harrison C, Campbell P, Green AR, Vannucchi A, Cross NC. 

Nature Communications (2015) 6: 6691 [Abstract] [Full Text]

 

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice combine to promote disease progression in myeloproliferative neoplasms

Chen E, Schneider RK, Breyfogle LJ, Rosen EA, Poveromo L, Elf S, Ko A, Brumme K, Levine R, Ebert BL, Mullally A.

Blood (2015) 125: 327-35 [Abstract] [Full Text]

 

2014

How does JAK2V617F contribute to pathogenesis of myeloproliferative neoplasms? (Review)

Chen E and Mullally A.

Hematology Am Soc Hematol Educ Program (2014) 2014: 268-76 [Abstract] [Full Text]

 

JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint

Chen E*, Ahn JS*, Massie CE, Clynes D, Godfrey AL, Li J, Park HJ, Nangalia J, Silber Y, Mullally A, Gibbons R, Green AR (* denotes equal contribution)

Proc Natl Acad Sci USA (2014) 111: 15190-5 [Abstract] [Full Text]

 

JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease

Li J, Kent DG, Godfrey AL, Manning H, Nangalia J, Aziz A, Chen E, Saeb-Parsy K, Fink J, Sneade R, Hamilton TL, Pask DC, Silber Y, Zhao X, Ghevaert C, Liu P, Green AR.

Blood (2014) 123:3139-51 [Abstract] [Full Text]

 

Ectopic TLX1 epression accelerates malignancies in mice deficient in DNA-PK

Krutikov K, Zheng Y, Chesney A, Huang X, Vaags AK, Evdokimova V, Hough MR*, Chen E* (* denotes co-corresponding authors) 

PLoS One (2014) 26: e89649 [Abstract] [Full Text]

 

 

2013

Clonal analysis reveal associations of JAK2V617F homozygosity with hematological features, age and gender in PV and ET.

Godfrey AL, Chen E, Pagano F, Silber Y, Campbell PJ, Green AR

Haematologica (2013) 98: 718-21 [Abstract] [Full Text]

 

2012

Janus kinase deregulation in leukemia and lymphoma (Review)

Chen E, Staudt LM, Green AR.

Immunity (2012) 36: 529-4  [Abstract] [Full Text]

 

JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone.

Godfrey AL, Chen E, Pagano F, Ortmann CA, Silber Y, Belosillo B, Guglielmelli P, Harrison C, Reilly JT, Stegelmann F, Bijou F, Lippert E, McMullin MF, Boiron JM, Doehner K, Vannucchi AM, Besses C, Campbell PJ, Green AR.

Blood (2012) 120: 2704-7 [Abstract] [Full Text]

 

The transcription factor encyclopedia.

Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW.

Genome Res (2012) 13:R24  [Abstract] [Full Text]

 

2011

Mouse models of myeloproliferative Neoplasms: JAK of all grades. (Review)

Li J, Kent DG, Chen E, Green AR

Dis. Models Mech. (2011) 4:311-7 [Abstract] [Full Text]

 

2010

Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling.

Chen E, Beer PA, Godfrey AL, Ortmann CA, Li J, Costa-Pereira AP, Ingle CE, Dermitzakis ET, Campbell PJ, Green AR.

Cancer Cell (2010) 18: 524-35 [Abstract] [Full Text]

 

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia.

Li J, Spensberger D, Ahn JS, Anand S, Beer PA, Ghevaert C, Chen E, Forrai A, Scott LM, Ferreira R, Campbell PJ, Watson SP, Liu P, Erber WN, Huntly BJ, Ottersbach K, Green AR.

Blood (2010) 116: 1528-38 [Abstract] [Full Text]

 

Two routes to leukemic transformation following a JAK2 mutation-positive myeloproliferative neoplasm.

Beer PA, Delhommeau F, Lecouedic JP, Dawson MA, Chen E, Bareford D, Kusec R, McMullin MF, Harrison CN, Vannucchi A, Vainchenker W, Green AR

Blood (2010) 115: 2891-900 [Abstract] [Full Text]

 

Phosphorylation of HOX11/TLX1 on threonine-247 during mitosis modulates expression of cyclin B1.

Chen E*, Huang X*, Zheng Y, Li YJ, Chesney A, Ben-David Y, Yang E, Hough MR (* denotes equal contribution)

Mol. Cancer (2010) 9: 246 [Abstract] [Full Text]

 

prior to 2010

Id1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signalling.

Wood AD, Chen E, Donaldson IJ, Hattangadi S, Burke KA, Dawson MA, Miranda-Saavendra D, Lodish HF, Green AR, Gottgens B.

Blood. (2009) 114:1820-30 [Abstract] [Full Text]

 

Loss of UBR1 promotes aneuploidy and accelerates B cell lymphomagenesis in TLX1/HOX11-Transgenic mice.

Chen E, Kwon YT, Lim MS, Dubé ID, Hough MR (2006)

Oncogene, 25: 5752-63 [Abstract] [Full Text]

 

Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-Transgenic mice.

Chen E, Lim MS, Rosic-Kablar S, Liu J, Jolicoeur P, Dubé ID, Hough MR

Oncogene (2006) 25: 2575-2587 [Abstract] [Full Text]

 

Gene expression profiling in the inductive human hematopoietic microenvironment.

Zhao Y, Chen E, Li L, Gong B, Xie W, Nanji S, Dubé ID, Hough MR 

Biochem Biophys Res Comm (2004) 323: 703-11 [Abstract] [Full Text]

 

 

© 2019 Edwin Chen